I am a researcher in farm animal genetics and epigenetics at GenPhySE, INRAE, located in Toulouse, France. I joined the GenEpi team there in 2017, after a postdoctoral position in Anagha Joshi’s group at the Roslin Institute (Edinburgh, UK).
Now a computational biologist, I started at the bench studying binding sites of the DNA methylation reader MBD2 during oncogenic transformation during my PhD. In my postdoc, I developed visualisations and webtools of transcriptomic and epigenomic data, including Heat*seq and PEREpigenomics.
I am building up my geneticist skills at INRAE, doing eQTL detection in pigs, FAANG data visualisations, and planning projects in satiety regulation through induced epi-mutations.
PhD in cancer epigenetics, 2014
Cancer Research Center of Lyon, France
Master Degree in Biosciences, 2011
ENS de Lyon, France
French agrégation in life and earth sciences, 2010
ENS de Lyon, France
Better protocols and decreasing costs have made high-throughput sequencing experiments now accessible even to small experimental laboratories. However, comparing one or few experiments generated by an individual lab to the vast amount of relevant data freely available in the public domain might be limited due to lack of bioinformatics expertise. Though several tools, including genome browsers, allow such comparison at a single gene level, they do not provide a genome-wide view. We developed Heatseq, a web-tool that allows genome scale comparison of high throughput experiments chromatin immuno-precipitation followed by sequencing, RNA-sequencing and Cap Analysis of Gene Expression) provided by a user, to the data in the public domain. Heatseq currently contains over 12 000 experiments across diverse tissues and cell types in human, mouse and drosophila. Heat*seq displays interactive correlation heatmaps, with an ability to dynamically subset datasets to contextualize user experiments. High quality figures and tables are produced and can be downloaded in multiple formats. AVAILABILITY AND IMPLEMENTATION: Web application: http://www.heatstarseq.roslin.ed.ac.uk/ Source code: https://github.com/gdevailly CONTACT: Guillaume.Devailly@roslin.ed.ac.uk or Anagha.Joshi@roslin.ed.ac.ukSupplementary information: Supplementary data are available at Bioinformatics online.