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Comprehensive analysis of epigenetic signatures of human transcription control
Advances in sequencing technologies have enabled exploration of epigenetic and transcriptional profiles at a genome-wide level. The …
Guillaume Devailly, Anagha Joshi
Preprint Project
Transcript Analysis Reveals a Hypoxic Inflammatory Environment in Human Chronic Otitis Media With Effusion
Chronic otitis media with effusion (COME) is the most common cause of childhood hearing loss in the developed world. Underlying …
Mahmood F. Bhutta, Jane Lambie, Lindsey Hobson, Debbie Williams, Hayley E. Tyrer, George Nicholson, Steve D. M. Brown, Helen Brown, Chiara Piccinelli, Guillaume Devailly, James Ramsden, Michael T. Cheeseman
Causal Transcription Regulatory Network Inference Using Enhancer Activity as a Causal Anchor
Transcription control plays a crucial role in establishing a unique gene expression signature for each of the hundreds of mammalian …
Deepti Vipin, Lingfei Wang, Guillaume Devailly, Tom Michoel, Anagha Joshi
Dynamics of promoter bivalency and RNAP II pausing in mouse stem and differentiated cells
BACKGROUND: Mammalian embryonic stem cells display a unique epigenetic and transcriptional state to facilitate pluripotency by …
Anna Mantsoki, Guillaume Devailly, Anagha Joshi
Insights into mammalian transcription control by systematic analysis of ChIP sequencing data
BACKGROUND: Transcription regulation is a major controller of gene expression dynamics during development and disease, where …
Guillaume Devailly, Anagha Joshi
Delineating biological and technical variance in single cell expression data
Single cell transcriptomics is becoming a common technique to unravel new biological phenomena whose functional significance can only …
Angeles Arzalluz-Luque, Guillaume Devailly, Anna Mantsoki, Anagha Joshi
DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment
Breast cancer-associated fibroblasts (CAFs) have a crucial role in tumor initiation, metastasis and therapeutic resistance by secreting …
P. Mathot, M. Grandin, G. Devailly, F. Souaze, V. Cahais, S. Moran, M. Campone, Z. Herceg, M. Esteller, P. Juin, P. Mehlen, R. Dante
Meta-analysis of Liver and Heart Transcriptomic Data for Functional Annotation Transfer in Mammalian Orthologs
Functional annotation transfer across multi-gene family orthologs can lead to functional misannotations. We hypothesised that …
Pia Francesca Loren Reyes, Tom Michoel, Anagha Joshi, Guillaume Devailly
Gene expression variability in mammalian embryonic stem cells using single cell RNA-seq data
BACKGROUND: Gene expression heterogeneity contributes to development as well as disease progression. Due to technological limitations, …
Anna Mantsoki, Guillaume Devailly, Anagha Joshi
Heat*seq: an interactive web tool for high-throughput sequencing experiment comparison with public data
Better protocols and decreasing costs have made high-throughput sequencing experiments now accessible even to small experimental …
Guillaume Devailly, Anna Mantsoki, Anagha Joshi